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The profile and characteristics of
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antidepressive
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action of all the drugs taken into consideration are comparable (including slightly more expressed sedative and deliberative effects
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discount prescription drugs canada of Amitriptyline
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( Elavil )). Unconditional multivariate logistic regression was used to estimate odds ratios for hyponatraemia in
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antidepressants
on other antidepressant drugs. Psychotropic profile of essential antidepressants (Amitriptyline ( Elavil ), imipramine, desipramine, chlorimipramine). Comparative
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studyComparative
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studies of the therapeutic activity of Amitriptyline ( Elavil ), imipramine, desipramine and chlorimipramine were studied in a group of 185 patients with endogenous depression. To estimate the risk of, and risk
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factors for, hyponatraemia associated with the use of selective serotonin reuptake inhibitors
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(SSRIs) compared with the use of other antidepressant drugs. Association between antidepressant drug use and hyponatraemia. SSRIs were
antidepressants
associated with an increased risk of hyponatraemia (OR 3.3; 95% CI 1.3, 8.6) compared with other classes of antidepressant drugs.
Desinhibitive influence of desipramine and imipramine was not proved. Neither was tachythymoleptic activity of desipramine found. The study does not support the relation between the antidepressive action profile
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of tricyclic antidepressants and their influence on reuptake of monoamines (norepinephrine and serotonine). A case-control study of psychiatric in- and out-patients
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on antidepressant drugs performed in the mid-southern part of The Netherlands over a 2 year period. Information on blood sodium concentrations was obtained from clinical chemistry data while information
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on drug use was obtained from community and hospital pharmacy databases. After standard 28-day treatment, the best results were obtained while using Amitriptyline ( Elavil ) (improvement rate 67%, the greatest reduction in the Lionel Depression Scale scored on 28-day of the treatment).
Cases (n 29) were all using antidepressant drugs with a serum sodium concentration of < or 130 mmol l(-1) while controls (n 78) were patients on antidepressants with a normal sodium concentration (136-144 mmol l(-1)). Medical records were used to ascertain possible risk and confounding factors. This adverse drug reaction was more com in older patients (>
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or 65 years) and in those using diuretics.. SSRIs are more frequently associated with hyponatraemia than other classes of antidepressant drugs. Stratified and interaction analyses revealed that elderly patients using diuretics concomitantly with SSRIs were at the highest risk of experiencing hyponatraemia (OR 13.5; 95% CI 1.8, 101).
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